A Word about Dopamine and Desire

CONSIDER THE REST OF THIS POST AS A THOUGHT EXPERIMENT.

Many people who have read about ‘game’ understand the connection between danger, impulsiveness, novel sensation and the feelings they create in women. Monoamine neurotransmitters in the ‘normal’ brain (serotonin, noradrenaline and dopamine) exist in a dynamic equilibrium. Depending on moods, conditions, challenges, amount of sunlight etc.. the balance can shift around. Since this dynamic balance works nicely in most people, there is no need to alter it. However conditions like serious depression, hypomania etc can change the balance requiring drugs to treat it.. yadada.

Many of you are aware of the libido dampening effects of serotonin reuptake inhibitors (SSRIs) like fluoexteine- prozac, paroxetine-paxil etc. But here is a question, what if you could block dopamine reuptake instead of noradrenaline or serotonin. Well, there are exclusive (or almost exclusive) dopmaine reuptake inhibitors (SDRIs) , however these compounds are not generally approved as drugs. The drugs listed in the previous link are not pure DRIs, and instead closer to selective dopamine-noradernaline reuptake inhibitors (SDNRIs).

Dopamine agonist such as apomorphine, bromocriptine and L-Dopa could work but carry the unpleasant side effect of significant nausea and some effects on body movement with chronic use (rebound/ adaptive effects).

Commonly available prescription drugs that are reasonably selective dopamine reuptake inhibitors are few-

Amphetamine (Adderall)
Methylphenidate (Ritalin) and
Bupropion (Wellbutrin, Zyban)

While methamphetamine and cocaine could also have similar effects, their pharmacokinetic characteristic + legal issues make them unsuitable. Moreover cocaine has a strong direct vasoconstrictor effect in addition to a autonomous nervous system mediated effect- resulting in the well-known adverse effects of cocaine on erections.

Note that methamphetmaine, amphetamine and cocaine also cause neurotransmitter release in addition to blocking its reuptake. That is why an addict can mistake amphetamine for methamphetamine (or vice versa), but rarely will they mistake methylphenidate or bupropion for either.

While methylphenidate and bupropion can be mistaken for each other by a casual user, bupropion’s effects last much longer than is desirable for certain uses.

Realistically, your choice is between amphetamine (Adderall) or methylphenidate (Ritalin).

Note that all three drugs (amphetamine, methylphenidate and bupropion) have been successfully used to treat female sexual dysfunction. However they also make people feel happy, and your greedy puritan overlords and their ‘capitalism’ believing slaves (right wingers) do not like that.

An interesting question is:

What type of synergistic effect can be obtained with alcohol (3-6 beers) and say.. 1/4th of 1/2 a daily dosage of these compounds in an otherwise healthy woman – when used occasionally (not daily).

In any case, most people with ADHD, atypical depression, narcolepsy and partial brain damage can take them for years without any significant side-effects.

While alcohol relaxes the person (partly through GABA receptor activation) it also makes people drowsy and clumsy. These drugs counteract the drowsy and clumsiness induced by alcohol, and in turn alcohol reduces the edginess and nervousness caused by noradrenaline reuptake- leaving behind a more purer dopaminergic effect.

So you have a relaxed person, who is very alert, lucid (maybe even more than normal) who has an acute need and strong desire to have sex and otherwise experience human touch. This state is very different from that caused by MDMA-Ecstasy. The person will remember every minor detail of the experience, even more vividly than otherwise and is not consent impaired.

Of course, the person who is taking this combination has to be attracted to the other person, to begin with. If there is no chemistry beforehand, nothing will happen as only consent and pre-existing willingness will focus that desire on the other person.

But once the focusing starts, it is hard to stop because it feels so good and amazing.

Comments?

  1. Nestorius
    July 20, 2010 at 2:29 pm

    More details need to be tested:

    1) How can we be sure that if there is no chemistry beforehand, nothing will happen as only consent and pre-existing willingness will focus that desire on the other person? If she is not attracted, might it work?
    —–

    If she is spending time with you by herself, she might be into you.

    2) What is exactly desire in the female? What does she want? Is it a feeling of a vagina that needs penetration? What’s the relation between the tingle and the dopamine?
    —–

    🙂

    • Nestorius
      July 20, 2010 at 3:19 pm

      The question answers itself: dopamine is the agent behind the strong tingle which eliminates LMR.
      —-

      It certainly causes them to tingle a lot, or so I hear.

      • Nestorius
        July 21, 2010 at 1:14 am

        You give me no choice but try the experiment by myself…

        On yourself?

  2. July 20, 2010 at 7:46 pm

    What type of synergistic effect can be obtained with alcohol (3-6 beers) and say.. 1/4th of 1/2 a daily dosage of these compounds in an otherwise healthy woman – when used occasionally (not daily).

    I can’t answer that question exactly, but I can share what I know from experience.

    According to my shrink, drugs like bupropion have no effect on people with normal brain chemistry. I strongly suspect that a teeny tiny dose like what you just described, taken only occasionally, would have no effect whatsoever.
    —-

    These effects are not as prominent with bupropion, which is far less selective for dopamine over noradrenaline that the other two.

    Now as a regualr bupropion user, I am not supposed to consume alchohol in excess, and I can attest that when I did get drunk, I did some extremely stupid things and ended up in a bunch of trouble. I can’t really say as to whether or not I was consent impaired, because I was having a mental breakdown at the time. Also, I was taking Ambien nightly and Xanax occasionally, which really, REALLY screwed up my memory. I was definitly not lucid, and to this day I still can’t remember everything that happened.

    But that’s just my case. As I said, I really don’t think a person with a normally funtioning brain would be affected at all.

  3. Hughman
    July 22, 2010 at 9:46 am

    Mephedrone was great when it was legal. Too good actually. I was very quickly gaining psychological dependence on it.

    What wasn’t there to like? I could dance all night. Kino flowed from me naturally. I could talk to anyone with a great frame. No caring about rejections. LAstin longer in the sack.

    Sure, it had its problems. Dry mouth being the big one, but nothing free soda can’t beat. Also, losing all want to eat. But again, no biggy, my hangovers from drink effect my gut worse.
    —-

    Hey Hughman,

    Why not find out yourself if certain drugs + alcohol truly increase horniness in women.

  4. Gorbachev
    July 22, 2010 at 11:01 pm

    This can be tested.

  5. July 31, 2010 at 9:13 am

    Why not just try something more regullar, a female libido enhancer for example. Having in mind there are those available on the market these days, why make awkward experiments.
    —-

    You have no idea how well certain things work.

  6. GP
    September 5, 2021 at 8:37 pm

    AD, this is one of your best posts.
    Can you please write another one with similar theme?
    This is amazing

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