Home > Critical Thinking, Current Affairs, Dystopia, Musings, Philosophy sans Sophistry, Reason, Secular Religions, Skepticism, Technology > A Very Intriguing Theory about Possible Artificial Origins of COVID-19

A Very Intriguing Theory about Possible Artificial Origins of COVID-19

A couple of days ago, I came across a rather long medium post about how COVID-19 aka SARS-2 might have been created in a laboratory rather than through natural selection. While I considered posting a link to it yesterday, it was prudent to do some due diligence first. See.. part of my job and training involves using software tools similar to the ones used in that post, so I decided to first independently verify a few of the main sequence alignments, structural models of proteins and publications etc before promoting it. Well.. while I have not re-verified every single point of data in this post, whatever I have done to date suggests that its main conclusions are correct.

Here is the post: SARS-CoV-2 Genealogy Through the Lens of Gain-of-Function Research

Since this post is very long and technical, let me summarize it- very briefly. The author starts by pointing out the unusual coincidence of an absolutely minimal furin cleavage site evolving at the junction of S1 and S2 subunits of the Spike protein in SARS-2. This is suspicious since gain of function by natural mutations usually tend to first create less than optimal sequences for new functions before being optimized via evolutionary selection. But this virus is too new for such an optimization to have occurred naturally- at least, that is not the most likely explanation.

He then points out that the two viruses which SARS-2 is most similar to ones discovered a few years ago (2014 and 2017/2019) in two different parts of the China. The Bat virus (RaTG13 with 96% similarity) came from a faecal swab from bat droppings from some cave in a part of China that is over 1,000 km from Wuhan, while the Pangolin virus (MP789 – 70% something similarity) came from autopsy of a bunch of smuggled sick pangolins from Malaysia in 2017. He then compares their sequences and while the Bat virus (RaTG13) is very similar to SARS-2, the Pangolin Virus has considerable dissimilarity with SARS-2 in first quarter of sequence for Spike Protein. Homologous recombination in a host infected with two viruses of same “species” without a segmented genome requires them to be very similar to each other.

More curiously, the new furin cleavage site in SARS-2 is a “gain of function” mutation, which means that it allows the virus to be more pathogenic (more infectious or capable of infecting a wider range of hosts/ cell types). It should be noted that more than a couple western research groups tried to insert similar enzymatic cleavage sites into other Coronaviruses such as SARS, MERS etc in the past. So it is not unreasonable to assume that the Chinese group in that Wuhan lab might have also tried it. In fact, we know that multiple research groups in Beijing tried that same gain of function mutation in a chicken Coronavirus. Oh ya.. and they also showed that putting that site into the S protein of another bat Coronavirus allowed it to infect human cells.

He then goes on talk about the whole field of Coronavirus research including many publications by a prominent researcher named Ralph Baric, who pioneered many of these techniques used for creating “gain of function” mutations in Coronaviruses. And yes.. he collaborated with the head of that Wuhan Coronavirus lab over the years, so it is makes perfect sense that you would see some his techniques are used in the later’s lab. Long story short, they looked at many “gain of function” mutations which made the resultant viruses deadlier. Also, Baric’s work seems to be have been “inspirational” to the lab in Wuhan since they kept trying out his ideas on Bat Coronaviruses.

The author then goes on to point out that accidental “leaks” of viruses from secure labs are far more common than most people realize, and are almost always due to poorly or hastily trained staff. So the idea that a poorly trained or careless researcher getting infected, but not developing serious illness and going on to spread it outside the lab is far more plausible than many would like to believe. He also points out the restriction enzyme map of nucleotide sequence, necessary for many types of genetic engineering, is rather similar for SARS-2, Bat and Pangolin coronvirus. And there are some other unusual similarities between the nucleotide codons used for certain amino acids- The explanation for which is a bit technical and complicated.

To summarize, the likelihood that this virus was created (along with others) to study effect of various “gain of function” mutations in Coronaviruses but then accidentally released into community through the actions of a poorly trained junior researcher is much more likely than it evolving naturally from a bat Coronavirus found in some remote part of the Yunnan province in China somehow magically recombining with a Pangolin Coronavirus from Malaysia and gaining just the right fragment of the Spike protein from it.

What do you think? Comments?

  1. April 26, 2020 at 7:50 pm

    Dr Fauci funded viral research at the Wuhan lab in 2014 at the same time that Obama was killing US viral research. Why would Obama permit his NIAID director to divert US funds to a foreign nation to conduct research which Obama considered too inherently dangerous?

    Harvard prof ((( Charles Lieber ))) is currently being prosecuted in the US for espionage for his viral research activities at the Wuhan lab.

    just the circumstantial evidence would indicate that that CoViD-19 is almost certainly designed.

    but whether it’s designed or an accident of Nature’s God, there is no question that China tried to weaponize it against the rest of the world.

  2. bonzo
    April 27, 2020 at 5:14 am

    Trigger alert: not for the weak of stomach.
    Rumor I heard was that, after creating this new virus, researchers infected a monkey with it. Monkey died or was euthanized, then examined, then remains placed into a biohazard waste container for disposal. Then some stupid, poorly paid but enterprising janitors retrieved the dead monkey from the container and sold to a meat soup street vendor at the nearby wet market. Janitors and their manager were all executed after being questioned. Soup vendor and unknown number of his customers died of natural causes (covid-19). Horrifying story was hushed up, but CIA learned of it through spies.

    • Joe Bloue
      April 27, 2020 at 11:20 am

      where did u read this?

      • plus d'un cafard
        April 30, 2020 at 9:45 pm

        The script he was handed by his superior.

  3. Yusef
    April 27, 2020 at 10:53 am

    As you may know, I have carefully studied this blog for some time. I have an in-depth knowledge of what AD got right and what he got wrong. He has spoken confidently and drawn on his professional expertise as he discussed the Covid-19 “pandemic” so therefore it is quite awful some of his most heinously wrong prognostications have been in this area. I will wait for an official apology before I post again, if ever.

    • doldrom
      April 27, 2020 at 8:54 pm

      Promise or threat? This does not seem to be much of a trigger and confirms a lot of things others have been saying for quite a while.

    • April 27, 2020 at 11:23 pm

      oh noes. the wonderful Yusef might never post again!

      *back of hand to forehead*

      • David H F*cktrelle. Male feminist Extraordinaire
        April 28, 2020 at 6:01 pm

        Roberto Mandalindino,

        you can know find the insightful posting of the wonderful, pro male feminist Yusef at my blog…

        But don’t comment unless you give up your male privilege…

    • David H F*cktrelle. Male feminist Extraordinaire
      April 28, 2020 at 5:58 pm

      Yusef,

      Thanks for leaving those comments at my blog telling me about this terrible kyriarchical misogyny…

      http://www.wehuntedthemammoth.com/2020/04/28/scientists-test-whether-giving-men-estrogen-could-help-them-survive-coronavirus-and-conspiracy-theorists-run-wild/

      • April 28, 2020 at 6:19 pm

        i applaud you for testing whether or not the Tolerance of a self professed ‘devil’s advocate’ extends to tolerating an actual devil, F*cktrelle.

  4. P Ray
    April 27, 2020 at 1:17 pm

    I like the part where someone who either was time- or financially-pressured didn’t get the training or did something slapdash and provided the virus the means to escape into the wider community.
    Just like how bubonic plague created the middle class, I wonder what kind of social evolution or destruction CoViD-19 will bring.
    Already it has destroyed the plans of thots and dinner-whores to be seen in expensive restaurants, as many are closed or do not offer the dine-in option anymore.

  5. Rum
    April 27, 2020 at 3:41 pm

    Influenza viruses are known to mutate naturally at a high rate. (That is a big reason why the 1918 bug faded away.) Therefore, it would make little sense to invest very much in creating a killer virus of that type.
    Corona viruses, on the other hand, are notably stable genetically, once emergent.
    Jus sayin…

    • P Ray
      April 27, 2020 at 11:18 pm

      https://www.dailymail.co.uk/health/article-8237849/Coronavirus-mutated-Strains-evolved-far-deadlier-spread-Europe-New-York.html
      Coronavirus has mutated to become far deadlier in Europe than the milder strain that made its way to the US west coast, Chinese study claims
      Researchers in China have found at least 30 strains of the SARS-CoV-2 virus
      Some of the deadliest mutations were found in Zhejiang, as well as in Europe
      The most severe strains could generate up to 270 times as much viral load
      Milder mutations were mostly found in the US, such as in Washington state

      I wonder how much it would cost to get 30 injections, on the flip side by the time many women are married they have seen such variance in pricks so that won’t be a new experience for them

  6. David H F*cktrelle, Mael Feminist Extraordinaire
    April 28, 2020 at 5:56 pm

    Which one of you, which one of you kyriarchical misogynists left this on my website?

    When I find out, I am gonna tell Amanda Marcotte and Hugo Shwyzer…

    We will then tell Amy Schumer to tell the gig chuck to ban you !!!

    • April 28, 2020 at 6:31 pm

      David Fucktrelle, the creature who would sacrifice both of its nuts in order to get 1/10th the pussy that women freely and willingly gave to fellow Leftist-Feminist, Harvey Weinstein.

      good thing its got that unnaturally powerful left hand.

      • David H F*cktrelle. Male feminist Extraordinaire
        April 28, 2020 at 10:57 pm

        Your just jealous I get transgina…

        You are obsessed with self-lubricating vajayjay from a woman born woman, you terf bigot you!!!!

        http://www.wehuntedthemammoth.com/2019/06/26/check-out-the-vaginal-mucus-on-her-and-other-things-straight-dudes-say-to-each-other-according-to-some-terf/

        yeah, sometimes I have to get ’em real drunk just like roost v, and, sometimes when they don’t stop crying afterwords I have to give ’em money like advocates diabolical. And if I have to throw my weight around, I just sit on ’em because I am after all about 350 pounds of lucious manboobage !!!!

        “Seriously, as long as a cis guy has some place to put his dick, or maybe a couple of options (not all of them necessarily located on the bottom half of the body), he’s generally pretty pleased.”

        Read it and weep, trans gina is real ‘gina, you terry bigot you!!!

      • April 29, 2020 at 3:23 pm

        it really can’t get much more amusing than an avowed devotee of Saint Darwin and the Survival of the Fittest mincing about, bragging how unfit he is to reproduce.

      • David H F*cktrelle. Male feminist Extraordinare
        April 29, 2020 at 6:55 pm

        Reproduction is overrated, Roberterto Mandalindrio…

        It is the part of neo-liberal feminism to have an abortion clinic on every corner along with a fast food restaurant…

        …and, let me let you in on a little “secret.” When we talk about abortion, we want to get rid of those icky minorities just as much as you do but we can’t say it out loud.

        In fact, the beloved margaret sanger/planned parenthood was a huge eugenicist…

        https://en.wikipedia.org/wiki/Margaret_Sanger

        So, jus remember, when you are sticking your peewee in a womyn born womyn….

        …and I know you are not high status enough to get a white woman-the holy grail of pu$$y…

        …if she doesn’t coat hanger the little bugger…

        …well, if it’s a boy, you will have a little eliot rodger…

        …and f a girl, she *will* do pr0n…

        so just let me know and I can claim it was for *research*

      • David H F*cktrelle. Male feminist Extraordinaire
        April 29, 2020 at 7:12 pm

        and, Boberto,

        you have the wrong idea about male feminists, we watch lots of porn and pressure woman into sex (also trannies but claim they are woman so we don’t seem gay…)

        “Hell, there’s even an entire genre of porn devoted to this process. All he needs to do is to go to his favorite porn site and type “creampie” in the search box to see an assortment of short featurettes highlighting this biological reality. (Or he could just check out Urban Dictionary, which helpfully defines “creampied” in somewhat mangled English as “The woman which vagina is fulfilled of cum during the orgasm.”)”

        http://www.wehuntedthemammoth.com/2020/01/27/young-man-worried-his-girlfriend-has-a-cancer-because-his-dudes-keep-spilling-out-of-her-gynecological-region/

        As long as we bash low status men (preferably non-white) we can keep the “pro-feminist” monicker…

        Harvey Weinstein is our guy because he is a progressocryte…

        too bad he got in trouble and we have to publicly disown him…

  7. MikeCA
    April 30, 2020 at 10:40 am

    I must say the quality of comments on this blog have gone down hill.

    I am skeptical of this. A semi-scientific article published on Medium.com does not seem to me like a very reliable source.

    Most of the argument seems to be it is possible for the virus to have been accidentally released from a lab, but there is really no evidence that it was. The people pushing the idea seem to be China haters or Trump supporters.

    By the way, there seems to be a lot of similarity in the way Putin and Trump have approached the virus. Both Putin and Trump “closed the border/banned travel” with China on Jan 31st. Russia of course has an actual border with China. Both Putin and Trump appear to have thought they had solved the Covid-19 problem by closing the border. Both Russia and the US had almost no testing available, so they had no idea how rapidly Covid-19 was spreading. Both Putin and Trump boasted about dealing with the problem. Now that there are 60K+ Americans dead from Covid-19 and mile long lines of ambulances trying to deliver patients to hospitals in Russia, both Putin and Trump have decided to blame governors for not being prepared to deal with the pandemic.

    Have Trump and Putin been discussing this on the phone?

    • David H F*cktrelle. Male feminist Extraordinaire
      April 30, 2020 at 1:03 pm

      Glad to see you are on my side.

      We gotta stop that horrid Tara Read (Russian bot troll) from derailing the greatest politician of our century… No, Not Hillary Rodham Clinton. Joseph Biden, the greatest gaffer and neo-liberal ever!

      https://www.currentaffairs.org/2020/03/tara-reade-tells-her-story

      Remember, believe ALL womyn when they are accusing a non-white man with absolutely no evidence. But destroy them if they get in the way of our neo-liberal feminist conquest of the western world!

    • doldrom
      April 30, 2020 at 9:32 pm

      No direct evidence; we are dealing with a forensically sophisticated set up. And there is a lot of ideology at stake, virologists and the science crowd don’t want to be put in a bad light for doing gain of function research contrary to treaties and good sense.

      BUT, there is a lot of circumstantial evidence. How about President Xi addressing the nation on Feb 14 and proclaiming new stricter controls and protocols for biolabs. As close to a confession as you are likley to get.

      Direct evidence for zoonotic origin is also totally lacking, only some speculation about how it might possibly have occurred, but goes nowhere near finding any direct evidence of similar viruses making the jump but not transmitting, or similar virus strains in bats or other species. Then there is the problem of the hibernating bats 1200km south of Wuhan, and nohere near Guanzhou where previous Chinese zoonotic viruses came from.

      No direct evidence applies to both branches of this fork equally. Circumstantial evidence is strong, though, and having the country’s only P4 BSL lab right there, involved with exactly the kind of research that makes such an accident, requires greater faith in coincidence than the prevalence of such events provides.

      Unless genetic forensis or other clues leads to conclusions, my guess is that we will never know, and there are a lot of interests tied to that outcome.

    • plus d'un cafard
      April 30, 2020 at 10:11 pm

      The quality of the comments has gone down because this blog is being shilled. If you’re a boomer this might sound preposterous, but younger, more nimble minds routinely share evidence and slip-ups exposing this practice, from the FBI to the army (not to mention the Chinese, Israel, …).

      The cleavage site you can go check yourself with the data that’s been made public. There’s plenty of evidence that the Wuhan lab was working on exactly the kind of virus we got, with American money and know-how.

      Peer-reviewed, published research is usually impossible to replicate and you will never get the data when you ask the researcher for it. Is that a more reliable source to you?

      Do you find, say, Macron’s handling of the virus better? Why keep the criticism to the people you don’t like.

      • David H F*cktrelle. Male feminist Extraordinare
        April 30, 2020 at 11:41 pm

        Oh hai “more than a COCK-roach…

        You disgusting MRA types always rather have a drug reference or penis reference in their name. And in the case of you and that horrid stonerwithaboner fella, both…

        For that, I am seriously triggered and will have too look at hours of transgendered erotica to bleach my brain of your het cis privilege…

        “The cleavage site you can go check yourself with the data that’s been made public.”

        Oh, subtle way to reference my sight you kyriarchical misogynist, you…

        We are now called “We Hunted the Mammoth (and ate it, too!)

        Yeah, I may take part of something someone actually said and then misrepresent by putting my own words behind it and then putting a flashing “Sarcasm” button for plausible deniability. So what. Yes, us feminists hate low status men but we cover it up with sarcasm and hide behind “social justice.”

        And as far as Macron. He is an excellent neo-liberal leader. Those stinky yellow jackets should work harder for less money and complain less. I hope Joe Biden can achieve similar excellent results in the US.

      • crackhead with a limp dick
        May 1, 2020 at 6:29 am

        I wish we could have such an excellent and yummy leader in the US as Macron.

        I dream about such things night and day.

      • Jack Donovan
        May 1, 2020 at 9:05 am

        oh lala…

        Macaroni looks “scared” but his booty says take me…

        We got the newest video in case Mike CA and Yusef make there way down to the wolves of vineland as they’ve been promising to doo…

  8. plus d'un cafard
    May 6, 2020 at 6:06 am

    Hey hey, what’s happening over there… https://www.zerohedge.com/health/researcher-cusp-covid-19-breakthrough-killed-bizarre-murder-suicide

    AD, computational biology, interest in the virus… watch your back.

  1. No trackbacks yet.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.

%d bloggers like this: